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Treat with foresight
nAMD

MULTI-TARGETED MOA

 

See EYLEA®

in action

EYLEA® Mode of Action Video

2020/03/27 - Bayer Ophthalmology
Multi Targeted MOA

STRONG

VEGF-binding affinity up to ~100-fold vs ranibizumab1

 

BROAD

Unique multi-targeted trap is the only anti-VEGF that blocks all VEGFR-1 ligands, including VEGF and PGF1,a

 

LONG-LASTING

Delivers long-lasting anti-VEGF activity up to 2x longer than ranibizumab2-4

 

 

In the treatment of DME,

even with complete VEGF blockade by ranibizumab or bevacizumabb, PGF would still be available to bind VEGFR-1 allowing, for example, further escalation of inflammation in DME1,5-7

Pre-Filled Syringe Pre-Filled Syringe

INTRODUCING THE NEW EYLEA® PRE-FILLED SYRINGE

WHAT'S INSIDE MAKES THE DIFFERENCE

 

Syringe cap with a simple twist mechanism, for controlled opening1

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References

  • Papadopoulos N, Martin J, Ruan Q, et al. Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis. 2012;15;171-185. Return to content
  • Muether PS, Hermann MM, Dröge K, Kirchhof B, Fauser S. Long-term stability of vascular endothelial growth factor suppression time under ranibizumab treatment in age-related macular degeneration. Am J Ophthalmol. 2013;156:989-993. Return to content
  • Fauser S, Muether PS. Clinical correlation to differences in ranibizumab and aflibercept vascular endothelial growth factor suppression times. Br J Ophthalmol. 2016;100:1494-1498. Return to content
  • Fauser S, Schwabecker V, Muether PS. Suppression of intraocular vascular endothelial growth factor during aflibercept treatment of age-related macular degeneration. Am J Ophthalmol. 2014;158:532-536. Return to content
  • Al Kahtani E, Xu Z, Al Rashead S, et al. Vitreous levels of placental growth factor correlate with activity of proliferative diabetic retinopathy and are not influenced by bevacizumab treatment. Eye (Lond). 2017;31:529-536. Return to content
  • Nguyen QD, De Falco S, Behar-Cohen F, et al. Placental growth factor and its potential role in diabetic retinopathy and other ocular neovascular diseases. Acta Ophthalmol. 2018;e1-e9. Return to content
  • Autiero M, Luttun A, Tjwa M, Carmeliet P. Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders. J Thromb Haemost. 2003;1:1356-1370. Return to content